Novel heterocycle-substituted pyrimidines as inhibitors of NF-κB transcription regulation related to TNF-α cytokine release

First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors:  Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's Disease

Ana Martı́nez, Mercedes Alonso, Ana Castro et al. · Journal of Medicinal Chemistry · 2002 · 447 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacotherapy +13

Pyrazole Urea-Based Inhibitors of p38 MAP Kinase:  From Lead Compound to Clinical Candidate

John R. Regan, Steffen Breitfelder, Pier F. Cirillo et al. · Journal of Medicinal Chemistry · 2002 · 350 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation

B.D. Bax, Paul S. Carter, Ceri Lewis et al. · Structure · 2001 · 199 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Genetic Deletion of Glycogen Synthase Kinase-3β Abrogates Activation of IκBα Kinase, JNK, Akt, and p44/p42 MAPK but Potentiates Apoptosis Induced by Tumor Necrosis Factor

Yasunari Takada, Xianjun Fang, Md Saha Jamaluddin et al. · Journal of Biological Chemistry · 2004 · 182 citations · Full text

Life Sciences, Cell Biology, Genetics +14

Glycogen Synthase Kinase-3β Regulates NF-κB1/p105 Stability

Francesca Demarchi, Cosetta Bertoli, Péter Sandy et al. · Journal of Biological Chemistry · 2003 · 160 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13