Nano Letters · 2006 · 163 citations · 11 references
EngineeringBioengineeringBiomedical EngineeringDiagnostic ImagingDrug DeliveryNanomaterialsContrast AgentsContrast MediaLipid-based NanoparticlesMagnetic Resonance ImagingNanomedicineNanoparticle FormulationsAtherosclerotic Plaque CharacterizationAtherosclerotic Plaque ImagingBioimaging NanomaterialsNanoparticle Contrast AgentsNanoparticle Imaging AgentsNanoparticle Imaging ProbesNanoparticle-based Contrast AgentsNanoparticles
The need for more specific and selective contrast agents for magnetic resonance imaging motivated us to prepare a new nanoparticle agent based on high-density lipoproteins (HDL). This second generation contrast agent can be prepared in three different ways. The HDL nanoparticles (rHDL) were fully characterized by FPLC and gel electrophoresis. The flexibility of the platform also allows us to incorporate optical probes into rHDL for localization ex vivo by confocal fluorescence microscopy. The contrast-agent-containing nanoparticles were injected into mice that develop atherosclerotic lesions. Magnetic resonance imaging of the animals showed clear enhancement of the atherosclerotic plaques.
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Glycoconjugates of gadolinium complexes for MRI applications
David A. Fulton, Elisa M. Elemento, Silvio Aime et al. · Chemical Communications · 2006 · 89 citations
Tova Chajek‐Shaul, Tony Hayek, A Walsh et al. · Proceedings of the National Academy of Sciences · 1991 · 72 citations