Analytical Letters · 1993 · 25 citations · 16 references
PharmacyPharmaceutical AnalysisPharmacologyAnalytical ChemistryBiopharmaceuticsChromatographic AnalysisAnalytical ChromatographyChromatographic Analysis Of PharmaceuticalsChromatographyLiquid ChromatographySpectroscopic Analysis Of PharmaceuticalsToxicological Screening Of PharmaceuticalsConcentrationHigh-performance Liquid ChromatographyHigh-performance Liquid Chromatography AnalysisHigh-performance Liquid Chromatography Method DevelopmentMinimum Inhibitory Concentration TestingUltraviolet-visible DetectionUv-visible Quantitative Analysis
Abstract A method for the determination of ofloxacin in pharmaceutical forms is described. The procedure is based on the use of the high-performance liquid chromatography, and of the second-derivative ultraviolet spectra, by utilizing the linear relationship between substance concentration and derivative peak amplitude. The minimum concentration detectable by derivative spectrophotometry was 20 ng/ml, and by HPLC 10 ng/ml. The proposed methods, which give thoroughly comparable data, are simple and rapid, and allow precise and accurate results.
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In vitro and in vivo activity of DL-8280, a new oxazine derivative
Kenichi Sato, Yoshiharu Matsuura, Manabu Inoue et al. · Antimicrobial Agents and Chemotherapy · 1982 · 279 citations · Full text
Medicine, Microbiology, Pharmacology +16