Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine

One-step inactivation of chromosomal genes in <i>Escherichia coli</i> K-12 using PCR products

Kirill A. Datsenko, Barry L. Wanner · Proceedings of the National Academy of Sciences · 2000 · 15.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

An efficient recombination system for chromosome engineering in <i>Escherichia coli</i>

Daiguan Yu, Hilary Ellis, E-Chiang Lee et al. · Proceedings of the National Academy of Sciences · 2000 · 1.7K citations

Life Sciences, Biotechnology, Genetics +16

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

Guoqiang Gu, Jolanta Dubauskaite, Douglas A. Melton · Development · 2002 · 1.5K citations

Life Sciences, Cell Biology, Developmental Biology +16

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Johan H. van Es, Mariëlle van Gijn, Orbicia Riccio et al. · Nature · 2005 · 1.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

<i>neurogenin3</i> is required for the development of the four endocrine cell lineages of the pancreas

Gérard Gradwohl, Andrée Dierich, Marianne LeMeur et al. · Proceedings of the National Academy of Sciences · 2000 · 1.5K citations

Life Sciences, Developmental Biology, Endocrinology +17