Advanced Materials · 2010 · 378 citations · 32 references
Natural SciencesChemistryPharmaceuticsDrug DeliveryNanomaterialsSurface ScienceCancer NanomedicineCoordination ChemistryNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanomedicineSurface Functionalization Of NanomaterialsChemical Surface FunctionalizationClick ChemistryClick Chemistry FunctionalizationClick Chemistry Surface ConjugationDrug Delivery NanocarriersNanoparticle Surface FunctionalizationSurface Functionalized NanomaterialsSurface-functionalized Nanoparticles
Porous coordination nanocages covered with alkyne groups are synthesized through judicious selection of the ligand and reaction conditions. The surface functionalization via click reaction with azide-terminated polyethylene glycol turns them into water-stable colloids, which exhibit controlled release of an anticancer drug 5-fluorouracil.
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