Angewandte Chemie International Edition · 2006 · 2K citations · 18 references
PharmacyPharmaceuticsPharmacologyBiomaterialsDrug DeliveryPharmaceutical FormulationDrug Delivery BiomaterialsDrug Delivery EngineeringDrug Delivery SystemsDrug FormulationMetal-organic Frameworks
Fill 'em up: The metal carboxylates MIL-100 and MIL-101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug-delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL-101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL-100) and 6 days (MIL-101).
18
A homochiral metal–organic porous material for enantioselective separation and catalysis
Jung Soo Seo, Dongmok Whang, Hyoyoung Lee et al. · Nature · 2000 · 3.9K citations
A New Property of MCM-41: Drug Delivery System
María Vallet‐Regí, A. Rámila, R. P. del Real et al. · Chemistry of Materials · 2000 · 2.2K citations