Selective Downregulation of the Angiotensin II AT₁-Receptor Subtype in Failing Human Ventricular Myocardium

Abstract

AT1 receptors are selectively downregulated in failing human ventricles, similar to the selective downregulation of beta 1 receptors. The relative lack of AT1 downregulation in ISC hearts may be related to differences in the degree of ventricular dysfunction.