Concepedia

Polymorphisms in the interleukin‐4 and interleukin‐4 receptor α chain genes confer susceptibility to asthma and atopy in a Caucasian population

Bianca Beghé, Sheila J. Barton, Steuart Rorke, Qiuju Peng, Ian Sayers, Tom R. Gaunt, T. P. Keith, Joanne Clough, S.T. Holgate, John W. Holloway

Clinical & Experimental Allergy · 2003 · 136 citations · 29 references

DOI

Abstract

Our data suggest that polymorphisms in the IL-4 and IL-4Ralpha chain genes might play a role both conferring susceptibility to and modulating severity of atopy and asthma.

References

29

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

Richard S. Spielman, Ralph McGinnis, Warren J. Ewens · PubMed · 1993 · 3.7K citations

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

Paul Van Eerdewegh, Randall D. Little, Josée Dupuis et al. · Nature · 2002 · 1.1K citations

, , +7

Interleukin-4: a prototypic immunoregulatory lymphokine

W E Paul · Blood · 1991 · 865 citations

The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor

Gurjit K. Khurana Hershey, Michal F. Friedrich, Laura A. Esswein et al. · New England Journal of Medicine · 1997 · 741 citations

Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy

Lanny J. Rosenwasser, Dwight J. Klemm, J DRESBACK et al. · Clinical & Experimental Allergy · 1995 · 553 citations

, , +10