Concepedia

Effects of an LL-37-Derived Antimicrobial Peptide in an Animal Model of Biofilm <i>Pseudomonas</i> Sinusitis

Sri Kiran Chennupati, Alexander G. Chiu, Edwin Tamashiro, Caroline A. Banks, Michael B. Cohen, Benjamin S. Bleier, Jennifer M. Kofonow, Eric Tam, Noam A. Cohen

American Journal of Rhinology and Allergy · 2009 · 94 citations · 33 references

DOI

Abstract

High concentrations of LL-37-derived peptide showed in vivo ability to eradicate Pseudomonas biofilms and decrease bacterial counts. However, increasing concentrations of peptide showed proinflammatory and ciliotoxic effects on sinus mucosa.

References

33

The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms

Howard Ceri, Merle S. Olson, Carol A. Stremick et al. · Journal of Clinical Microbiology · 1999 · 2.1K citations · Full text

Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

De Yang, Qian Chen, Albert P. Schmidt et al. · The Journal of Experimental Medicine · 2000 · 1.2K citations · Full text

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Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis

Mitchell J. Goldman, G.Mark Anderson, Ethan D. Stolzenberg et al. · Cell · 1997 · 1.1K citations · Full text

Conformation-dependent Antibacterial Activity of the Naturally Occurring Human Peptide LL-37

Jan Johansson, Guðmundur H. Guðmundsson, Martı́n E. Rottenberg et al. · Journal of Biological Chemistry · 1998 · 657 citations · Full text

A cathelicidin family of human antibacterial peptide LL‐37 induces mast cell chemotaxis

François Niyonsaba, Kazuhisa Iwabuchi, Akimasa Someya et al. · Immunology · 2002 · 398 citations · Full text