A chemical phylogeny of group I introns based upon interference mapping of a bacterial ribozyme

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

François Michel, Éric Westhof · Journal of Molecular Biology · 1990 · 1.2K citations

Life Sciences, Bioinformatics, Molecular Biology +13

Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing

J.H.D. Cate, Anne R. Gooding, Elaine R. Podell et al. · Science · 1996 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +17

A general two-metal-ion mechanism for catalytic RNA.

Thomas A. Steitz, J A Steitz · Proceedings of the National Academy of Sciences · 1993 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +17

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

Thomas R. Cech, Arthur J. Zaug, Paula J. Grabowski · Cell · 1981 · 890 citations · Full text

Life Sciences, Genetics, Molecular Biology +8

The Chemistry of Self-Splicing RNA and RNA Enzymes

Thomas R. Cech · Science · 1987 · 531 citations

Life Sciences, Biochemistry, Chemistry +17