Concepedia

Ribozyme-mediated Cleavage

Ribozyme-Mediated Cleavage is a biochemical process in which a ribozyme, functioning as a catalytic RNA molecule, selectively hydrolyzes a specific phosphodiester bond within an RNA substrate, thereby distinguishing it from protein enzyme-mediated cleavage mechanisms.

908

Publications

51.8K

Citations

2.4K

Authors

618

Institutions

Publications per year

2017–2026

41

Parents

Publications

908

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

W. G. Scott, J.T. Finch, Aaron Klug · Cell · 1995 · 686 citations · Full text

, , +14

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents

Nava Sarver, Edouard M. Cantin, Pairoj S. Chang et al. · Science · 1990 · 663 citations

, , +15

Kinetics of RNA Degradation by Specific Base Catalysis of Transesterification Involving the 2‘-Hydroxyl Group

Yingfu Li, Ronald R. Breaker · Journal of the American Chemical Society · 1999 · 590 citations

, , +17

Directed Evolution of an RNA Enzyme

Amber Beaudry, Gerald F. Joyce · Science · 1992 · 453 citations

, , +16

Crystal structure of a hairpin ribozyme–inhibitor complex with implications for catalysis

Peter B. Rupert, A.R. Ferré-D′Amaré · Nature · 2001 · 441 citations

, , +14

1–5 of 908

Authors

2.4K

  1. TR
    Thomas R. Cech

    Howard Hughes Medical Institute, United States

    24 publications · 3.6K citations

    24

    h-index

  2. KT
    Kazunari Taira

    National Institute of Advanced Industrial Science and Technology, Japan

    28 publications · 1.2K citations

    21

    h-index

  3. DH
    Daniel Herschlag

    Stanford University, United States

    17 publications · 2.2K citations

    17

    h-index

  4. JJ
    John J. Rossi

    City of Hope, United States

    22 publications · 1.7K citations

    17

    h-index

  5. DM
    David M.J. Lilley

    University of Dundee, United Kingdom

    16 publications · 944 citations

    16

    h-index

1–5 of 2.4K

Institutions

618

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    40 h-index

    134 publications

    15.9K citations

  2. University of Colorado Boulder

    Boulder, United States

    25 h-index

    74 publications

    8K citations

  3. Yale University

    New Haven, United States

    21 h-index

    88 publications

    11K citations

  4. University of Vermont

    Burlington, United States

    20 h-index

    64 publications

    4.2K citations

  5. National Institute of Advanced Industrial Science and Technology

    Tsukuba, Japan

    19 h-index

    105 publications

    4.5K citations

  6. Duke Medical Center

    Durham, United States

    19 h-index

    50 publications

    4.5K citations

  7. Stanford University

    Stanford, United States

    18 h-index

    55 publications

    4.5K citations

  8. University of California, Berkeley

    Berkeley, United States

    17 h-index

    84 publications

    4.7K citations

1–8 of 618

Venues

  1. Nucleic Acids Research

    132 publications · 5.7K citations

    45

    h-index

  2. Biochemistry

    93 publications · 5.5K citations

    45

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 54 publications · 4.7K citations

    41

    h-index

  4. PubMed

    Repository · 47 publications · 2K citations

    27

    h-index

  5. Journal of the American Chemical Society

    JACS · 38 publications · 2.5K citations

    27

    h-index

1–5