Annals of Neurology · 1997 · 84 citations · 12 references
MedicineGeneticsNeurologyDementiaGenetic EpidemiologyMedical GeneticsAlzheimer DiseaseDementia EpidemiologyDementia GeneticsDementia Risk FactorsGenotype-phenotype Association AnalysisNeurodegenerative Disease GeneticsAllele FrequencyAlzheimer Disease EpidemiologyAlzheimer Disease RiskApoe GeneticsApolipoprotein E Genotype RiskApolipoprotein E VariantsGenotype Data AnalysisRacial Disparities In Dementia
As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE epsilon4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in epsilon4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the epsilon3/epsilon3 genotype, but the OR for AD with the epsilon3/epsilon4 genotype did not reach significance (1.20; 95% CI, 0.58-2.45). These findings suggest that the association between ApoE epsilon4 and AD is weaker in African Americans than in whites.
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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Elizabeth H. Corder, Ann M. Saunders, Neil Risch et al. · Nature Genetics · 1994 · 1.9K citations
ApoE-4 and Age at Onset of Alzheimer's Disease
Deborah Blacker, Jonathan L. Haines, L. Rodes et al. · Neurology · 1997 · 487 citations