Concepedia

Oxindole synthesis by palladium-catalysed aromatic C–H alkenylation

Satoshi Ueda, Takahiro Okada, Hideko Nagasawa

Chemical Communications · 2010 · 112 citations · 38 references

DOI

Concepts

Abstract

A strategy involving palladium-catalysed aromatic C-H functionalisation/intramolecular alkenylation provides a convenient and direct synthesis of 3-alkylideneoxindoles. In the presence of 5 mol% of PdCl(2)MeCN(2) and AgOCOCF(3), a wide variety of N-cinnamoylanilines gave 3-alkylideneoxindoles in moderate to good yield.

References

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