Concepedia

Functionalized Chiral Ionic Liquid Catalyzed Enantioselective Desymmetrizations of Prochiral Ketones via Asymmetric Michael Addition Reaction

Sanzhong Luo, Long Zhang, Xueling Mi, Yupu Qiao, Jin‐Pei Cheng

The Journal of Organic Chemistry · 2007 · 109 citations · 4 references

DOI

Concepts

Abstract

Functionalized chiral ionic liquids were found to be highly effective and reusable organocatalysts for asymmetric Michael additions of 4-substituted cyclohexanones. The desymmetrization reaction afforded the desired Michael adducts bearing three carbon stereocenters with up to 99% ee.

References

4

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Diana Almaşi, Diego A. Alonso, Carmén Nájera · Tetrahedron Asymmetry · 2007 · 857 citations

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Catalytic enantioselective direct Michael additions of ketones to alkylidene malonates

Juan M. Betancort, Kandasamy Sakthivel, Rajeswari Thayumanavan et al. · Tetrahedron Letters · 2001 · 275 citations

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A Bimetallic, Coordinated‐Ketene Complex Formed from a Bimetallic Lithium–Carbon Spirocycle by Lithium‐Mediated Insertion of CO into a Rhodium–Carbon Bond

Min Fang, Nathan D. Jones, R. Lukowski et al. · Angewandte Chemie International Edition · 2006 · 32 citations

, , +11

A Bimetallic, Coordinated‐Ketene Complex Formed from a Bimetallic Lithium–Carbon Spirocycle by Lithium‐Mediated Insertion of CO into a Rhodium–Carbon Bond

Min Fang, Nathan D. Jones, R. Lukowski et al. · Angewandte Chemie · 2006 · 29 citations

, , +11