Insulin induces transcription of target genes through the hypoxia‐inducible factor HIF‐1α/ARNT

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer, Lori E. Kotch, Faton Agani et al. · Genes & Development · 1998 · 2.5K citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +16

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Gregg L. Semenza, G.L. Wang · Molecular and Cellular Biology · 1992 · 2.4K citations · Full text

Medicine, Genetics, Molecular Biology +17

<i>daf-2</i> , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in <i>Caenorhabditis elegans</i>

Koutarou D. Kimura, Heidi A. Tissenbaum, Yanxia Liu et al. · Science · 1997 · 2.3K citations

Life Sciences, Biology, Genetics +17

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

Gregg L. Semenza, Bing‐Hua Jiang, Sandra W. Leung et al. · Journal of Biological Chemistry · 1996 · 1.8K citations · Full text

Medicine, Molecular Biology, Molecular Genetics +15