Total Synthesis of (−)‐Basiliskamide B

Abstract

Abstract The total synthesis of the polyketide antibiotic (−)‐basiliskamide B is described. The convergent asymmetric synthesis relies on the use of a diastereoselective ethyl ketone aldol reaction followed by a syn selective reduction of a β‐hydroxy ketone and a Stille cross‐coupling between a Z ‐vinylstannane and an E ‐vinyl iodide to establish the (Z,E) ‐dienamide moiety.