ChemBioChem · 2010 · 98 citations · 37 references
Life SciencesBiochemistryMolecular BiologyDrug DesignProtein-protein InteractionsStructural BiologyHydrogen Bonding In BiomoleculesLigand BindingProtein StructureProtein-protein RecognitionStructural Basis Of RecognitionAlpha HelicesHydrogen Bonding In Molecular RecognitionProtein Binding In OncologyProtein-protein Recognition Motifs
Split kit: Synthetic helices target chosen protein–protein interactions with high specificity, as assessed by an in vitro split-protein reassembly assay. By using the p53/MDM2 complex as a model system, both the efficacy of the designed ligands and the suitability of the split-protein assay were determined.
37
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations
Medicine, Oncology, Pharmacology +15
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
Loren D. Walensky, Andrew L. Kung, Iris Escher et al. · Science · 2004 · 1.3K citations · Full text
Direct inhibition of the NOTCH transcription factor complex
Raymond E. Moellering, Melanie Cornejo, Tina Davis et al. · Nature · 2009 · 750 citations · Full text
Dieter Seebàch, James Gardiner · Accounts of Chemical Research · 2008 · 700 citations
Foldamers with Heterogeneous Backbones
W. Seth Horne, Samuel H. Gellman · Accounts of Chemical Research · 2008 · 682 citations · Full text