Transport of anthracyclines and mitoxantrone across membranes by a flip-flop mechanism

Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

F Szoka, Demetrios Papahadjopoulos · Proceedings of the National Academy of Sciences · 1978 · 2.3K citations · Full text

Natural Sciences, Biochemistry, Biophysics +16

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Fluorescence assay for phospholipid membrane asymmetry

Jonathan C. McIntyre, Richard G. Sleight · Biochemistry · 1991 · 488 citations

Life Sciences, Biochemistry, Cell Biology +10

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

Yossef Raviv, Harvey B. Pollard, Edward Bruggemann et al. · Journal of Biological Chemistry · 1990 · 392 citations · Full text

Medicine, Biochemistry, Pharmacology +16