Journal of the American Chemical Society · 2002 · 65 citations · 9 references
Life SciencesBiochemistryProtein BiochemistryProteomicsStructural BiologyPeptide AnalysisPeptide ChemistryProtein StructureSecondary StructureSecondary Structure FormationIon MobilityIon Mobility SpectrometryPeptide Mass SpectrometryPeptide Secondary StructurePeptide Stability AnalysisPeptide Structure AnalysisProtein Secondary Structure Analysis
Results from ion mobility studies of tryptic peptides suggest that, in some cases, the gas-phase structures can be related to the solution-phase structure of the parent protein. The interpretation of ion mobility measurements is supported by results from molecular modeling and H/D exchange experiments on the same peptides. This study clearly illustrates the utility of IM-MS for screening complex mixtures for peptides having intrinsically stable secondary/tertiary structures, and/or posttranslational modification.
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