Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

Salvatore Oddo, Antonella Caccamo, Jason D. Shepherd et al. · Neuron · 2003 · 4.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

Karen S. SantaCruz, Jada Lewis, Jennifer Paulson et al. · Science · 2005 · 2K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Alzheimer Disease-specific Conformation of Hyperphosphorylated Paired Helical Filament-Tau Is Polyubiquitinated through Lys-48, Lys-11, and Lys-6 Ubiquitin Conjugation

Diane Cripps, Stefani N. Thomas, Young Y. Jeng et al. · Journal of Biological Chemistry · 2006 · 314 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Reduction of Soluble Aβ and Tau, but Not Soluble Aβ Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles

Salvatore Oddo, Vitaly Vasilevko, Antonella Caccamo et al. · Journal of Biological Chemistry · 2006 · 276 citations · Full text

Life Sciences, Neurology, Neuroscience +17

5‐Lipoxygenase gene disruption reduces amyloid‐β pathology in a mouse model of Alzheimer's disease

Omidreza Firuzi, Jia‐Min Zhuo, Cinzia Maria Chinnici et al. · The FASEB Journal · 2007 · 175 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17