Biology of the Neonate · 2009 · 13 citations · 0 references
Life SciencesBiochemistryDevelopmental BiologyCellular MetabolismDevelopmental PhysiologyMetabolismDevelopmental MetabolismFatty Acid MetabolismFetal DevelopmentHepatic MetabolismLipid MetabolismLiver DevelopmentFatty Acid Chain ElongationFetal Hepatic MaturationFetal Liver MaturationHepatic Metabolic DevelopmentHepatic Microsomal MetabolismLipid Metabolism DevelopmentLiver Microsomal MetabolismRat Liver Microsomes
Long-chain fatty acid synthesis by rat-liver microsomes increases strikingly following birth. After a peak of activity at 11 days of age, microsomal synthesis declines until, coincident with the time of weaning, there is a rapid increase in activity to adult levels. Product identification indicates that microsomal fatty acid synthesis occurs primarily by chain elongation.