New insight on the photoreactivity of the phototoxic anti-cancer flutamide: photochemical pathways selectively locked and unlocked by structural changes upon drug compartmentalization in phospholipid bilayer vesicles

Abstract

It is shown that structural changes of the phototoxic anti-cancer drug flutamide after its compartmentalization in unilamellar phospholipid bilayer vesicles lead to a highly selective modification of the photochemical outcome, locking the main photodegradation pathways observed in homogeneous media and unlocking a new and more efficient photoreactive channel.