Publication | Closed Access
Some Properties of the Plasma hGH Activity in Patients with Laron-Type Dwarfism Determined by a Radioreceptor Assay Using Human Liver Tissue
16
Citations
0
References
1985
Year
Human GrowthPathologyPituitary GlandHematologyPlasma HghNuclear MedicineCirculating HghPlasma Hgh ActivityHealth SciencesRadiologyXenotransplantationGrowth HormoneLiver PhysiologyHistopathologyEndocrinologyLiver TransplantationHepatologyHuman Growth HormoneThyroid HormoneMedicineLaron-type Dwarfism
A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-old male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from 1 normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.