Interethnic Comparisons of Important Pharmacology Genes Using SNP Databases: Potential Application to Drug Regulatory Assessments

Abstract

A potential use of the analyses is for regulators to develop a decision tree based on the extent of population divergence in key drug targets, metabolizing enzymes or transporter pathways when reviewing foreign clinical trial data. The methodology can be readily extended to other genes and countries with diverse ethnic groups. We continue to explore ways of integrating the information from these population genetics tools into stratifying the risk that the drug response established in one population could be translated to another.