Continuous Flow System with a Polymer‐Supported Dirhodium(II) Catalyst: Application to Enantioselective Carbonyl Ylide Cycloaddition Reactions

Abstract

The immobilization of [Rh2(S-PTTL)(S-TCPTTL)3] (PTTL = N-phthaloyl-tert-leucinate, TCPTTL=N-tetrachlorophthaloyl-tert-leucinate) has been accomplished by copolymerization of the RhII-complex-containing monomer with 2-(trifluoromethyl)styrene and a flexible cross-linker. The immobilized catalyst promoted intermolecular carbonyl ylide cycloaddition reactions in CF3C6H5 under continuous flow conditions, where high yields as well as high levels of enantioselectivity and turnover number were achieved. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.