Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP

Magnesium gates glutamate-activated channels in mouse central neurones

Linda M. Nowak, Pìotr Bregestovski, Philippe Ascher et al. · Nature · 1984 · 4K citations

Life Sciences, Neurobiology, Neuroscience +14

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Richard Morris, Eric Anderson, Gary Lynch et al. · Nature · 1986 · 3.6K citations

Life Sciences, Neuroscience, Pharmacology +15

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

HS Chen, JW Pellegrini, SK Aggarwal et al. · Journal of Neuroscience · 1992 · 631 citations · Full text

Medicine, Neuroscience, Pharmacology +14

The Influence of Prior Synaptic Activity on the Induction of Long-Term Potentiation

Yan-You Huang, A. Colino, David K. Selig et al. · Science · 1992 · 416 citations

Life Sciences, Neurobiology, Neuroscience +17

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

Chris G. Parsons, René Gruner, Jouri Rozental et al. · Neuropharmacology · 1993 · 281 citations

Medicine, Pharmacology, Molecular Pharmacology +12