CHIP functions an E3 ubiquitin ligase of Runx1

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

Tsukasa Okuda, Jan M. van Deursen, Scott W. Hiebert et al. · Cell · 1996 · 1.9K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Identification of CHIP, a Novel Tetratricopeptide Repeat-Containing Protein That Interacts with Heat Shock Proteins and Negatively Regulates Chaperone Functions

Carol A. Ballinger, Patrice M. Connell, Yaxu Wu et al. · Molecular and Cellular Biology · 1999 · 934 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

E. Ogawa, Masato Maruyama, Hiroshi Kagoshima et al. · Proceedings of the National Academy of Sciences · 1993 · 614 citations

Life Sciences, Genetics, Molecular Biology +12

CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

Shu-Bing Qian, Holly McDonough, Frank Boellmann et al. · Nature · 2006 · 367 citations · Full text

Life Sciences, Molecular Biology, Gene Expression +10

Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin–proteasome‐mediated degradation

Gang Huang, Katsuya Shigesada, Kosei Ito et al. · The EMBO Journal · 2001 · 280 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14