p16 Alterations and retinoblastoma protein expression in squamous cell carcinoma and neighboring dysplasia from the upper aerodigestive tract

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

Alexander Kamb, Nelleke A. Gruis, Jane Weaver-Feldhaus et al. · Science · 1994 · 2.8K citations

Life Sciences, Genetics, Molecular Genetics +17

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Adrian Merlo, James G. Herman, Li Mao et al. · Nature Medicine · 1995 · 2K citations

Medicine, Genetics, Molecular Biology +17

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Manuel Serrano, Han‐Woong Lee, Lynda Chin et al. · Cell · 1996 · 1.6K citations · Full text

Medicine, Cancer Biology, Molecular Genetics +16

Genetic progression model for head and neck cancer: implications for field cancerization.

Joseph A. Califano, Peter van der Riet, William H. Westra et al. · PubMed · 1996 · 1.4K citations

Medicine, Genetics, Oncology +17

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

Mirella Gonzalez‐Zulueta, Christina M. Bender, A S Yang et al. · PubMed · 1995 · 712 citations

Medicine, Genetics, Oncology +17