Nucleic Acids Research · 2013 · 118 citations · 25 references
Life SciencesBiochemistryBioinformaticsComputational BiologyStructural BioinformaticsStructural BiologyMacromolecular Structure DeterminationProtein StructureProtein Structure ModelingComputational Structure PredictionProtein Model AssessmentProtein Model ValidationProtein Structure AssessmentProtein Structure Assessment MetricsProtein Structure ComparisonProtein Tertiary Structure PredictionQuality Assessment
Once you have generated a 3D model of a protein, how do you know whether it bears any resemblance to the actual structure? To determine the usefulness of 3D models of proteins, they must be assessed in terms of their quality by methods that predict their similarity to the native structure. The ModFOLD4 server is the latest version of our leading independent server for the estimation of both the global and local (per-residue) quality of 3D protein models. The server produces both machine readable and graphical output, providing users with intuitive visual reports on the quality of predicted protein tertiary structures. The ModFOLD4 server is freely available to all at: http://www.reading.ac.uk/bioinf/ModFOLD/.
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Basic local alignment search tool
Stephen F. Altschul, Warren Gish, Webb Miller et al. · Journal of Molecular Biology · 1990 · 94.5K citations
Structure validation by Cα geometry: ϕ,ψ and Cβ deviation
Simon C. Lovell, Ian Davis, W.B. Arendall et al. · Proteins Structure Function and Bioinformatics · 2003 · 4.6K citations