Concepedia

Publication | Open Access

Paracrine Modulation of CXCR4 by IGF-1 and VEGF: Implications for Choroidal Neovascularization

DOIFull Paper Access

48

Citations

36

References

2010

Year

Nilanjana Sengupta, Aqeela Afzal, Sergio Caballero, Kyung Hee Chang, Lynn C. Shaw, Ji‐Jing Pang, Vincent C. Bond, Imran Ahmed Bhutto, Takayuki Baba, Gerard A. Lutty,
Investigative Ophthalmology & Visual Science

Abstract

The potent proangiogenic factors IGF-1 and VEGF both stimulate SDF-1-induced angiogenesis. Local inhibition of CXCR4 is required for an antiangiogenic effect in CNV lesions.

References

YearCitations

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