Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist

Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes

Robert F. Bruns, James H. Fergus, Edward W. Badger et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 1987 · 377 citations

Life Sciences, Neuroscience, Pharmacology +9

Potent adenosine receptor antagonists that are selective for the A1 receptor subtype.

Ekaterina A. Martinson, Robert Johnson, Jack N. Wells · Molecular Pharmacology · 1987 · 62 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Selective A₁-Antagonists for Treatment of Cognitive Deficits

G. Schingnitz, U. Küfner-Mühl, Helmut A. Ensinger et al. · Nucleosides and Nucleotides · 1991 · 55 citations

Medicine, Neuroscience, Pharmacology +10

8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities

J Shimada, Fumio Suzuki, Hiromi Nonaka et al. · Journal of Medicinal Chemistry · 1991 · 50 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Natriuretic and hypotensive effect of adenosine-1 blockade in essential hypertension.

Marjolijn van Buren, Joost A. Bijlsma, Peter de Boer et al. · Hypertension · 1993 · 50 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17