Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTPγS binding

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

André DeLÉAN, Peter J. Munson, David Rodbard · American Journal of Physiology-Endocrinology and Metabolism · 1978 · 2.4K citations

Medicine, Biostatistics, Pharmacology +17

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

Jasmine Parma, Laurence Duprez, Jacqueline Van Sande et al. · Nature · 1993 · 923 citations

Medicine, Endocrinology, Genetics +12

Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT_1A and 5‐HT_1B agonists

Jeffrey Sprouse, George K. Aghajanian · Synapse · 1987 · 845 citations · Full text

Medicine, Neuroscience, Pharmacology +16

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

Andrew Shenker, Louisa Laue, Shinji Kosugi et al. · Nature · 1993 · 756 citations · Full text

Medicine, Endocrinology, Genetics +14