Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

Tatsuya Tamaoki, Hisayo Nomoto, ISAMI TAKAHASHI et al. · Biochemical and Biophysical Research Communications · 1986 · 2.5K citations

Life Sciences, Biochemistry, Pharmacology +10

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

Peter J. Parker, Lisa M. Coussens, Nick Totty et al. · Science · 1986 · 864 citations

Life Sciences, Biochemistry, Molecular Biology +17

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

Dionisio Martı́n-Zanca, Stephen H. Hughes, Mariano Barbacid · Nature · 1986 · 803 citations · Full text

Medicine, Molecular Biology, Oncology +16

A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.

Satoshi Ōmura, YUZURU IWAI, Atsushi Hirano et al. · The Journal of Antibiotics · 1977 · 672 citations · Full text

Life Sciences, Biochemistry, Microbiology +10

Presence of diadenosine 5',5''' -P1, P4-tetraphosphate (Ap4A) in mamalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator".

Eliezer Rapaport, Paul C. Zamecnik · Proceedings of the National Academy of Sciences · 1976 · 268 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13