Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

Education, Cell Biology, Molecular Biology +15

The limited in vitro lifetime of human diploid cell strains

Leonard Hayflick · Experimental Cell Research · 1965 · 5.8K citations

Life Sciences, Cell Biology, Genetics +9

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text

Medicine, Cell Biology, Oncology +10

Telomere length predicts replicative capacity of human fibroblasts.

Richard Allsopp, Homayoun Vaziri, Cam Patterson et al. · Proceedings of the National Academy of Sciences · 1992 · 2.2K citations · Full text

Life Sciences, Biology, Cell Biology +13

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

Andrew Lee, Brett E. Fenster, Hideki Ito et al. · Journal of Biological Chemistry · 1999 · 682 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17