Peritoneal Dialysis and Hemodialysis of Tritiated Digoxin

Abstract

Article1 October 1967Peritoneal Dialysis and Hemodialysis of Tritiated DigoxinGEORGE L. ACKERMAN, M.D., F.A.C.P., JAMES E. DOHERTY, M.D., F.A.C.P., WILLIAM J. FLANIGAN, M.D.GEORGE L. ACKERMAN, M.D., F.A.C.P., JAMES E. DOHERTY, M.D., F.A.C.P., WILLIAM J. FLANIGAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-4-718 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe problems raised by reduced excretion of certain drugs or their metabolites make a knowledge of clinical pharmacology important to physicians treating patients with renal insufficiency. The growing availability of chronic dialysis therapy likewise necessitates a familiarity with the behavior of commonly prescribed drugs during dialytic procedures. Chronic renal failure is often accompanied by hypertensive heart disease, for which digitalis or one of its glycosides may be prescribed. Electrocardiographic changes resembling those encountered with digitalis intoxication may be seen during dialysis (1), and alertness to digitalis toxicity during dialysis has been advised by Lubash and associates (2).We have studied...References1. KOHNKILEY RMJE: Electrocardiographic changes during hemodialysis, with observations on contribution of electrolyte disturbances to digitalis toxicity. Ann. Intern. Med. 39: 38, 1953. LinkGoogle Scholar2. LUBASHCOHENBRAVEMANRUBINLUCKEY GDBDWSALEH: Electrocardiographic changes during hemodialysis with the artificial kidney. Circulation 19: 552, 1959. CrossrefMedlineGoogle Scholar3. DOHERTYPERKINSMITCHELL JEWHGK: Tritiated digoxin studies in human subjects. Arch. Intern. Med. (Chicago) 108: 531, 1961. CrossrefMedlineGoogle Scholar4. DOHERTYPERKINSWILSON JEWHMC: Studies with tritiated digoxin in renal failure. Amer. J. Med. 37: 536, 1964. CrossrefMedlineGoogle Scholar5. MARCUSKAPADIAKAPADIA FIGJGG: The metabolism of digoxin in normal subjects. J. Pharmacol. Exp. Ther. 145: 203, 1964. MedlineGoogle Scholar6. FLANIGANHENDERSONMERRILL WJLWJP: The clinical application and technique of peritoneal dialysis. GP 28: 98, 1963. MedlineGoogle Scholar7. BOEN ST: Kinetics of peritoneal dialysis: a comparison with the artificial kidney. Medicine (Balt.) 40: 243, 1961. CrossrefGoogle Scholar8. WOLFREMPKILEYCURRIE AVGGJEGD: Artificial kidney function: kinetics of hemodialysis. J. Clin. Invest. 30: 1062, 1951. CrossrefMedlineGoogle Scholar9. BLOOMNELPTUELL PMWBSH: Relationship of the excretion of tritiated digoxin to renal function. Amer. J. Med. Sci. 251: 133, 1966. CrossrefMedlineGoogle Scholar10. MARCUSPETERSONSALELSCULLYKAPADIA FIAAJGG: The metabolism of tritiated digoxin in renal insufficiency in dogs and man. J. Pharmacol. Exp. Ther. 152: 372, 1966. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Little Rock, ArkansasFrom the Department of Medicine, University of Arkansas School of Medicine, and the Veterans Administration Hospital, Little Rock, Ark.This study was supported in part by grants HE 006642-(06) and FR-49, National Institutes of Health, Bethesda, Md., and by Burroughs Wellcome & Co. (U. S. A.) Inc., Tuckahoe, N. Y.This work was presented in part at the Third International Congress of Nephrology, September 27, 1966, Washington, D. C., and at the 16th Scientific Session of the American College of Cardiology, February 19, 1967, Washington, D. C.Requests for reprints should be addressed to George L. Ackerman, M.D., Department of Medicine, University of Arkansas Medical Center, Little Rock, Ark. 72201. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExtracorporeal treatment for digoxin poisoning: systematic review and recommendations from the EXTRIP WorkgroupDigoxin Therapy in the Elderly: Pharmacokinetic Considerations in NursingLandmark Publication from The American Journal of the Medical Sciences: The Clinical Pharmacology of Digitalis Glycosides: A ReviewPlasma exchange for the removal of digoxin-specific antibody fragments in renal failure: Timing is important for maximizing clearancePharmacologic alterations of peritoneal transport rates and pharmacokinetics of the peritoneumModel Systems Employing Affinity Chromatography for Extraction of Toxic Substances Directly from Whole BloodComments on Dialysis Solution, Antibiotic Transport, Poisonings, and Novel Uses of Peritoneal DialysisPharmacological Considerations for Renal Failure and DialysisTreatment of adverse digitalis effects by hemoperfusion through columns with antidigoxin antibodies bound to agarose polyacrolein microsphere beadsDigitalis Hemoperfusion: Increase of Column Binding Capacity by Pretreatment with OuabainPediatric toxicology: Current controversies and recent advancesSpecific hemoperfusion through agarose acrobeadsTherapy of digoxin intoxication in dogs by specific hemoperfusion through agarose polyacrolein microsphere beads-antidigoxin antibodiesComments on dialysis solution, antibiotic transport, poisoning, and novel uses of peritoneal dialysisComplications of peritoneal dialysis other than peritonitisPart III Digitalis glycosides: Mechanisms and manifestations of toxicityTHERAPEUTIC PROGRESS—REVIEW XIII.Part II Digitalis glycosides: Mechanisms and manifestations of toxicityPart I Digitalis glycosides: Mechanisms and manifestations of toxicityUse of Drugs in Uremia and DialysisSpecific Removal of Digoxin by Hemoperfusion Through Agarose Polyacrolein Microsphere Polyacrolein Microsphere Beads-Antidigoxin Antibodies (APAMB-AD)Drugs and Peritoneal DialysisDrugs and DialysisAnomalous Serum Digoxin Concentrations in UremiaJEFFREY L. CRAVER, M.D., ROLAND VALDES Jr., Ph.D.Therapie der HerzglykosidintoxikationDosierung von Herzglykosiden bei NiereninsuffizienzDie tödliche DigitalisintoxikationPharmacological Aspects of Renal Failure and DialysisAcute and chronic digitalis toxicity: Presentation and treatmentSuicidal digoxin poisoning: Conventional treatment and antibody therapyGlykosidtherapie bei NiereninsuffizienzEinfluß von Erkrankungen auf die Kinetik herzwirksamer Glykoside und dessen Bedeutung für die PraxisPharmacokinetics of Drugs during Various Detoxification Procedures for Overdose and Environmental ExposureHigh Output Cardiac Failure on Maintenance Hemodialysis Secondary to a Post-Biopsy Renal Arteriovenous FistulaPharmacokinetics of Digoxin in C.A.P.D.NephrologieThe Effect of Disease on Cardiac Glycoside PharmacokineticsComplications of Peritoneal Dialysis Other Than PeritonitisComments on Dialysis Solution Composition, Antibiotic Transport, Poisoning, and Novel Uses of Peritoneal DialysisClinical Pharmacology of Digitalis GlycosidesThe Peritoneal Handling of Digoxin during CAPDProperties of Agarose-Encapsulated Adsorbents I. Adsorption of Dixogin from Human SerumDigoxin Pharmacokinetics in Continuous Peritoneal DialysisSALVADOR PANCORBO, PHARM, D., PH.D., CHRISTINA COMTY, M.D.Drug Therapy in Renal Failure: Dosing Guidelines for Adults Part II: Sedatives, Hypnotics, and Tranquilizers; Cardiovascular, Antihypertensive, and Diuretic Agents; Miscellaneous AgentsWILLIAM M. BENNETT, M.D., RICHARD S. MUTHER, M.D., RICHARD A. PARKER, M.D., PETER FEIG, M.D., GAIL MORRISON, M.D., THOMAS A. GOLPER, M.D., IRWIN SINGER, M.D.Hemoperfusion of Digoxin IntoxicationStudies on cortisol metabolism during haemodialysis in manPeritoneal DialysisPharmacologic Aspects of Regular Dialysis TreatmentDigoxin Acute Intoxication: Evaluation of the Efficiency of Charcoal HemoperfusionDigoxin and digitoxin elimination in man by charcoal hemoperfusionPharmacokinetic evaluation of hemodialysis in acute drug overdoseClinical pharmacokinetics of digitalis glycosidesUse of Albumin-Cellulose Nitrate Microencapsulated Charcoal Hemoperfusion: in Acute Digoxin Toxicity in DogsPharmacokinetic Aspects of the Dialysis of DrugsGuidelines for Drug Therapy in Renal FailureWILLIAM M. BENNETT, M.D., F.A.C.P., IRWIN SINGER, M.D., F.A.C.P., THOMAS GOLPER, M.D., PETER FEIG, M.D., CECIL J. COGGINS, M.D.Drug administration in renal failureDirect Current Shock and Digitalis TherapyEntgiftungsbehandlung der chronischen Digitalis-Intoxikation durch Hämocolperfusion bei HundenElimination von Herzglykosiden durch HämofiltrationRelevanz von Hämodialyse oder Hämoperfusion zur Beschleunigung der Elimination von DigitalisglykosidenDigoxin elimination by exchange transfusionDigitalis pharmacokinetics and therapy with respect to impaired renal functionKlinische und pharmakokinetische Untersuchungen zur DigitalisintoxikationElimination of Cardiac Glycosides Through HemofiltrationMicroencapsulated Charcoal Hemoperfusion: A Possible Therapeutic Adjunct in Digoxin ToxicitySerum Digitalis Level—Practical ValueComplications of acute peritoneal dialysisOuabain Plasma Level Kinetics and Removal by Dialysis in Chronic Renal Failure A Study in Fourteen PatientsRICHARD SELDEN, M.D., GORDON HAYNIE, M.D.Pitfalls in the application of digoxin determinationsPharmacokinetics of digoxin and digitoxin in patients undergoing hemodialysisCurrent concepts of therapy with digitalis glycosides. Part IIDigitalisDigitalis Glycosides Pharmacokinetics and Their Clinical ImplicationsJAMES E. DOHERTY, M.D., F.A.C.P.Tritiated digoxinIDENTIFICATION OF AMPOULESREMOVAL OF PARACETAMOL BY HÆMOPERFUSIONTREATMENT OF DIGOXIN INTOXICATIONClinical Review : Peritoneal Dialysis in ChildrenFATAL INTOXICATION WITH DIGOXINEFFECT ON CHILD OF MATERNAL SMOKING DURING PREGNANCYOf Toads and FlowersTritiated Digoxin XVIIISelf-Poisoning with DigoxinDialysance und prozentuale Elimination verschiedener Herzglykoside w�hrend der H�mo- und PeritonealdialyseAssays of digitalis in the bloodClinical Pharmacology of DigoxinAn anaesthetic application of serum digoxin radioimmunoassayPeritoneal Dialysis: A ReviewAbsorption of Digitalis CompoundsDialysis of Poisons and DrugsTritiated digoxinExtracorporeal and Peritoneal Dialysis of DrugsConservative Management of Chronic Renal FailureTritiated DigoxinKinetik der Herzsteroide im Organismus des Menschen und der VersuchstiereElimination von H3-g-Strophanthin durch HämodialyseMetabolism of digitalisMedical management of chronic renal failureCortisolverlust und Plasma-11-Hydroxy-Corticosteroidprofil während der Hämodialyse 1 October 1967Volume 67, Issue 4Page: 718-723KeywordsExcretionGlycosidesHospital medicineIntoxicationMedical dialysisMetabolitesNephrologyPeritoneal dialysisRenal failureToxicity ePublished: 1 December 2008 Issue Published: 1 October 1967 PDF downloadLoading ...