Endocrinology · 1940 · 48 citations · 0 references
Life SciencesBiochemistryEndocrinologyMetabolic RegulationNeuroendocrinologySteroid BiochemistryAdrenal EndocrinologyAdrenal HormonesAdrenal Steroid HormonesCarbohydrate MetabolismGluconeogenesis RegulationInsulin TherapyAdrenal Cortex FunctionAdrenal Cortex PhysiologyAdrenal Cortical HormonesAdrenal PathophysiologyCarbohydrate CatabolismCarbohydrate Energy UtilizationGluconeogenesisHormonal Control Of Gluconeogenesis
THE ROLE of the adrenal cortex in promoting the formation of carbohydrate from protein sources has been demonstrated in experimental animals (1). Recently it has also been shown that adrenal cortical hormone therapy had a striking effect in regulating carbohydrate utilization as well as in facilitating gluconeogenesis in patients with Addison's disease (2). The present study was undertaken to investigate the relationship between the increase in carbohydrate utilization and the decrease in gluconeogenesis which has been observed in adrenal cortical insufficiency. It appeared possible that an inability to form glucose from intermediate products of carbohydrate catabolism as well as from protein catabolism could account for many of the abnormalities. In the present report the ability of adrenalectomized animals (phlorrhizin or insulin treated) to form glucose following the administration of potentially glycogenic substances has been studied. The comparative effectiveness of treatment with several adrenal cortical hormone preparations has also been observed.