Publication | Open Access
Using <i>Digest</i> to implement the pathway participation method for detecting influential system structure
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Citations
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References
2004
Year
EngineeringModeling MethodSimulation ModellingPathway Participation MethodComplex SystemsStochastic SimulationMetabolic NetworkSystems Dynamics ModelingSystems EngineeringBiostatisticsModeling And SimulationPathway ParticipationMetabolic Pathway AnalysisDynamic SystemsSystems AnalysisBiochemistryProcess AnalysisPathway AnalysisSample Digest RunInfluential System StructureBioinformaticsArticle Briefly DefinesBiologyNatural SciencesComputational BiologyProcess ControlRegulatory Network ModellingSystems BiologyProcess ModellingSystem Dynamic
Abstract This article briefly defines and describes the pathway participation metric (PPM), a mathematical calculation that can help to identify the linkages between the structure and behavior of a dynamic system. PPM has been implemented in an experimental piece of software called Digest , which we then present. Digest is not a simulation language, but rather a companion to any commercial system dynamics package, which accepts a text version of a simulation model and performs post formulation analysis of the model. Digest detects and displays which feedback loops are most influential in explaining a selected pattern of behavior in a model. Output from a sample Digest run is presented and described. Copyright © 2004 John Wiley & Sons, Ltd.
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