Experimental Biology and Medicine · 1955 · 19 citations · 0 references
Enzyme ContentLipid PeroxidationToxicological MechanismOxidative StressBlood Xanthine OxidaseBioanalysisToxicologyToxicological AspectClinical ChemistryClinical ToxicologyAnimal PhysiologyBiochemistryPoisoningExperimental ToxicologyPharmacologyCarbon TetrachloridePhysiologyForensic ToxicologyMetabolismMedicineXanthine Oxidase
SummaryQuantitative determinations of xanthine oxidase and dehydrogenase activity in blood serum of normal rats were made. It was shown that a single injection of 0.1 ml CCl4/100 g body weight is able to activate the blood xanthine oxidase and dehydrogenase, reaching the highest values 20-25 hours after injection. However, after 35 hours the values returned to normal. Activation of the enzyme was also obtained in vitro by adding CCl4 to a sample of serum of known enzyme content.