Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.3K citations

Life Sciences, Biochemistry, Molecular Biology +12

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Piotr Chomczyński, Nicoletta Sacchi · Analytical Biochemistry · 1987 · 46.9K citations

Life Sciences, Biochemistry, Molecular Biology +12

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

AnthonyW. Linnane, Takayuki Ozawa, S Marzuki et al. · The Lancet · 1989 · 1.2K citations

Life Sciences, Genetics, Molecular Genetics +12

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Marisol Corral‐Debrinski, Terzah M. Horton, Marie T. Lott et al. · Nature Genetics · 1992 · 886 citations

Life Sciences, Genetics, Neuroscience +16

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

Patrizia Mecocci, Usha MacGarvey, A. Kaufman et al. · Annals of Neurology · 1993 · 757 citations

Life Sciences, Genetics, Neuroscience +15