Radical Cyclization of Allylic Haloacetamides. A Route to cis-Fused 2-Pyrrolidones and Piperidones

Abstract

A variety of N-protected haloacetamides undergo efficient radical cyclization to produce N-protected lactams.The protecting groups can be removed under a range of different conditions.Recently, we reported1 the syntheses of various lactones using a free radical cyclization of bromoacetals and subsequent Jones oxidation.In an attempt to develop