In Situ Cryo-Crystallization of Fluorinated Amines: A Comparative Study of Cooperative Intermolecular Interactions Involving Ordered and Disordered Fluorine

Abstract

The low-temperature crystal structures of 4-fluoroaniline and 2-fluoroaniline, determined following in situ crystal growth from the liquid, reveal the importance of both strong hydrogen bonds and weak intermolecular interactions involving fluorine generating different packing motifs in the crystalline solid in the isomeric molecules.