Concepedia

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

Michael J. Evans, Alan Saghatelian, Erik J. Sorensen, Benjamin F. Cravatt

Nature Biotechnology · 2005 · 228 citations · 25 references

DOI

Concepts

References

25

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Sonam Dolma, Stephen L. Lessnick, William C. Hahn et al. · Cancer Cell · 2003 · 1.4K citations · Full text

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Activity-Based Protein Profiling in Vivo Using a Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

Anna E Speers, Gregory C. Adam, Benjamin F. Cravatt · Journal of the American Chemical Society · 2003 · 948 citations

, , +17

Profiling Enzyme Activities In Vivo Using Click Chemistry Methods

Anna E Speers, Benjamin F. Cravatt · Chemistry & Biology · 2004 · 767 citations · Full text

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Glycolytic Enzymes Can Modulate Cellular Life Span

Hiroshi Kondoh, Matilde E. Lleonart, Jesús Gil et al. · Cancer Research · 2005 · 639 citations · Full text

, , +17

Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin

Shenping Liu, Joanne Widom, Christopher W. Kemp et al. · Science · 1998 · 437 citations

, , +15