Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation

Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes.

Ping‐Yee Law, D S Hom, Horace H. Loh · Molecular Pharmacology · 1983 · 217 citations

Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation.

Ann Tempel, Eliot L. Gardner, R. Suzanne Zukin · Journal of Pharmacology and Experimental Therapeutics · 1985 · 204 citations

Narcotic Receptor Sites in Morphine-dependent Rats

Werner A. Klee, Richard A. Streaty · Nature · 1974 · 201 citations

Molecular Pharmacology, Addiction, Medicine +8

Naltrexone-induced opiate receptor supersensitivity

R. Suzanne Zukin, Jonathan R. Sugarman, Melissa L. Fitz-Syage et al. · Brain Research · 1982 · 196 citations

Molecular Pharmacology, Addiction, Medicine +5

Chronic naloxone results in prolonged increases in opiate binding sites in brain

Robert A. Lahti, R. James Collins · European Journal of Pharmacology · 1978 · 170 citations

Neuropsychology, Psychoactive Drug, Chronic Naloxone Results +13