Mild basic ionic liquids catalyzed new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

Recent Advances in Solution-PhaseMulticomponent Methodology for the Synthesis of HeterocyclicCompounds

Romano V. A. Orrù, Michiel de Greef · Synthesis · 2003 · 925 citations

Pharmacy, Chemistry, Medicinal Chemistry +9

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

N.K. Terrett, Andrew Bell, David Brown et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 606 citations

Medicine, Pharmacology, Pharmacotherapy +12

Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant:  Lead Identification and SAR of 3- and 4-Substituted Derivatives

Michaël Génin, Carolyn Biles, Barb J. Keiser et al. · Journal of Medicinal Chemistry · 2000 · 378 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis and Anticonvulsant Activity of Novel and Potent 6,7-Methylenedioxyphthalazin-1(2<i>H</i>)-ones

Silvana Grasso, Giovambattista De Sarro, Angela De Sarro et al. · Journal of Medicinal Chemistry · 2000 · 211 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

4-Benzylamino-1-chloro-6-substituted Phthalazines:  Synthesis and Inhibitory Activity toward Phosphodiesterase 5

Nobuhisa Watanabe, Yasuhiro Kabasawa, Yasutaka Takase et al. · Journal of Medicinal Chemistry · 1998 · 210 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10