Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

Inflammation, Cytokine, Signal Transduction +13

Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)

Yoshikatsu Kanai, Hiroko Segawa, Ken‐ichi Miyamoto et al. · Journal of Biological Chemistry · 1998 · 1.1K citations · Full text

Functional Properties, Immunology, Expression Cloning +20

mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

Diane C. Fingar, Celeste Richardson, Andrew R. Tee et al. · Molecular and Cellular Biology · 2003 · 867 citations · Full text

Rapamycin-resistant Mutant, Signal Transduction, Signaling Pathway +13

Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines

Osamu Yanagida, Yoshikatsu Kanai, Arthit Chairoungdua et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2001 · 728 citations

Signal Transduction, Biochemistry, Oncogenic Agent +11

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

Aimee L. Edinger, Craig B. Thompson · Molecular Biology of the Cell · 2002 · 583 citations · Full text

Apoptosis, Cell Death, Cell Proliferation +23