Spectral Studies and In Vitro Antimicrobial Activity of New Organotin(IV) Complexes of Schiff Bases Derived from Amino Acids

Abstract

Abstract Some new di- and triphenyltin(IV) complexes of the general formulae Ph2SnL and Ph3SnL′, where H2L/HL′ = Schiff bases derived from the condensation of 2-hydroxy-1-naphthaldehyde (H2L) and benzaldehyde (HL′) with glycine (H2L-1/HL′-1), Dl-α-alanine (H2L-2/HL′-2), l-methionine (H2L-3/HL′-3), Dl-valine (H2L-4/HL′-4), d-phenylalanine (H2L-5/HL′-5), 2-aminobutyric acid (H2L-6/HL′-6), and l-leucine (H2L-7/HL′-7), have been synthesized and characterized by elemental analyses, molar conductance, electronic, infrared and far-infrared, multinuclear magnetic resonance (1H, 13C, and 117Sn), and 119Sn Mössbauer studies. Thermal decomposition of a few complexes using TG, DTG, and DTA techniques indicates the formation of SnO2 as a residue. The complexes have also been tested in vitro against bacteria [Streptococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus Penicillin resistance (2500 units)] and fungi [Candida albicans, Cryptococcus neoformans, Sporotrichum schenckii, Trichophyton mentagrophytes, and Aspergillus fumigatus]. All of the complexes show remarkable activity.