Effects of temperature and mexiletine on the F1473S Na + channel mutation causing paramyotonia congenita

Molecular Determinants of State-Dependent Block of Na ⁺ Channels by Local Anesthetics

David S. Ragsdale, Jancy C. McPhee, Todd Scheuer et al. · Science · 1994 · 861 citations

Medicine, Neuroscience, Pharmacology +17

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

James W. West, D E Patton, Todd Scheuer et al. · Proceedings of the National Academy of Sciences · 1992 · 839 citations

Natural Sciences, Neurobiology, Neuroscience +17

Lidocaine block of cardiac sodium channels.

Bruce P. Bean, Charles J. Cohen, Richard W. Tsien · The Journal of General Physiology · 1983 · 660 citations · Full text

Medicine, Pharmacology, Physiology +17

Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation

Mohamed Chahine, Alfred L. George, Ming Zhou et al. · Neuron · 1994 · 345 citations · Full text

Natural Sciences, Molecular Genetics, Physiology +17

Adynamia episodica hereditaria with myotonia: A non‐inactivating sodium current and the effect of extracellular pH

Frank Lehmann‐Horn, G. Küther, K. Ricker et al. · Muscle & Nerve · 1987 · 239 citations · Full text

Life Sciences, Neurology, Physiology +16