Cross-linked aggregates of penicillin acylase: robust catalysts for the synthesis of β-lactam antibiotics

Penicillin Acylase in the Industrial Production of β-Lactam Antibiotics

Alle Bruggink, Eric C. Roos, Erik de Vroom · Organic Process Research & Development · 1998 · 313 citations

Penicillin Acylase, Engineering, Antimicrobial Susceptibility +15

Effect of pH in the synthesis of ampicillin by penicillin acylase

Sonia Ospina, Eduardo Bárzana, Octavio T. Ramı́rez et al. · Enzyme and Microbial Technology · 1996 · 88 citations

Penicillin Acylase, Medicinal Chemistry, Biosynthesis +7

[26] Equilibrium and kinetically controlled synthesis with enzymes: Semisynthesis of penicillins and peptides

Volker Kasche, Ursula Haufler, Lutz Riechmann · Methods in enzymology on CD-ROM/Methods in enzymology · 1987 · 87 citations

Biosynthesis, Bioorganic Chemistry, Engineering +9

Use of aqueous two-phase systems for in situ extraction of water soluble antibiotics during their synthesis by enzymes immobilized on porous supports

Odette Hernández-Jústiz, Roberto Fernández‐Lafuente, Marco Terreni et al. · Biotechnology and Bioengineering · 1998 · 85 citations

Enzymic synthesis of cephalosporins

Takeshi Takahashi, Yoshio Yamazaki, Koichi Kato et al. · Journal of the American Chemical Society · 1972 · 62 citations

Enzymic Synthesis, Biosynthesis, Bioorganic Chemistry +15