Cytochrome P-450-catalyzed stereoselective epoxidation at the K region of benz[a]anthracene and benzo[a]pyrene

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

Allan H. Conney · PubMed · 1982 · 1.6K citations

Medicine, Biochemistry, Toxicology +16

Arene Oxides: A New Aspect of Drug Metabolism

D. M. JERINA, John W. Daly · Science · 1974 · 1K citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.

Linda M. Reik, Dene E. Ryan, Wayne Levin · Journal of Biological Chemistry · 1981 · 303 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

Dhiren R. Thakker, Haruhiko Yagi, H. Akagi et al. · Chemico-Biological Interactions · 1977 · 262 citations

Medicine, Chemistry, Pharmacology +12

Benzo[ <i>a</i> ]pyrene Diol Epoxides: Mechanism of Enzymatic Formation and Optically Active Intermediates

Shen K. Yang, D W McCourt, Janet C. Leutz et al. · Science · 1977 · 134 citations

Pharmacy, Biochemistry, Enzymology +16