Organic Letters · 2006 · 51 citations · 19 references
Natural SciencesChemical EngineeringChemistryCatalysisOrganometallic ChemistryReaction EngineeringCatalyst DesignCatalyst PreparationCatalytic MaterialsCatalytic MechanismsCatalytic Reaction EngineeringMetal CatalysisCatalyst ActivationPrecursor CompoundsReaction Efficiency OptimizationSubstrate ScopeSubstrate Scope ExpansionSubstrate Scope ProfilingSubstrate Scope Screening
The presence of catalytic amounts of halide salts was found to enhance dramatically the reaction efficiency in the Ru-catalyzed hydroesterification of alkenes and alkynes using a chelating 2-pyridylmethyl formate by lowering the reaction temperature. On the basis of IR and NMR studies, the halide effect on the reaction is mainly attributed to the facile dissociation of the trirutheniumcarbonyl precursor into the presumed active metal species. With this milder condition, the substrate scope has been significantly broadened.
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Efficient catalytic addition of aromatic carbon-hydrogen bonds to olefins
Shinji Murai, Fumitoshi Kakiuchi, Shinya Sekine et al. · Nature · 1993 · 1.4K citations